Native Porcine Creatine Kinase MM

Cat No.

NATE-0959

Description

Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene. In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme. In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

Abbr

CK-MM, Native (Porcine)

Alias

CK-MM

Source

Porcine Skeletal Muscle

Species

Porcine

Applications

Diagnostic Controls, Calibrators & Standards; Clinical Chemistry; Testing/Assay Validation; Life Science; Manufacturing

Form

Liquid; 50% Glycerol, 50 mM TrisCl, 2.5 mM b-mercaptoethanol, 0.05% NaN3

Molecular Weight

43 kDa

Purity

> 90% (SDS-PAGE)

Concentration

> 1.0 mg/mL

Optimum pH

Typically 8.0

Stability

2 years

Storage

Store at -20°C

Synonyms

CKM; creatine kinase, muscle; CKMM; creatine kinase M-type; creatine kinase-M; creatine kinase M chain; M-CK; MM-CK

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