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Enzymes for Research, Diagnostic and Industrial Use

ON-01910

Cat No.
CEI-0303
Description
ON 01910 can inhibit polo-like kinase 1 (Plk1) with IC50 of 9 nM.
CAS No.
1225497-78-8
Molecular Weight
473.47
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PLK1
Molecular Formula
C21H24NNaO8S
Solubility
DSMO Water Ethanol
In vitro
ON 01910 is a novel polo-like kinase 1 (Plk1) inhibitor and it inhibit PLK1 with IC50 of 9 nM. ON 01910 also shows cytotoxic activity against a variety of human tumor cell lines in vitro. ON 01910 can induce three major abnormalities in tumor cells, including abnormal cell division (irregular chromosomal segregation and cytokinesis), G2-M arrest and apoptosis, and decreased expression of Cdc25C in many tumor cell lines.
In vivo
In rats, single doses of 300 and 600 mg/m 2 of ON01910 produced no toxicity, and 1200 mg/m2 had only slight toxicity. There was no evidence of significant myelotoxicity, neuropathy, or cardiotoxicity in these toxicology studies. In xenograft mouse model systems, ON01910 inhibited the growth of a wide variety of human tumors, including liver, breast, and pancreatic cancers.
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