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PJ34

Cat No.
CEI-0985
Description
A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.
Abbr
PJ34
Appearance
White to light brown powder.
CAS No.
344458-15-7
Molecular Weight
331.8 Da
Purity
>98%
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Synonyms
N-(5,6-Dihydro-6-oxo-2-phenanthridi­nyl)-2-acetamide hydrochloride
Targets
PARP
IC50
20 nM
Molecular Formula
C17H17N3O2 • HCl
Solubility
Soluble to 100 mM in water and to 100 mM in DMSO
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