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Enzymes for Research, Diagnostic and Industrial Use

Palomid 529 (P529)

Cat No.
CEI-0084
Description
Palomid 529 inhibits both VEGF-driven and bFGF-driven endothelial cell proliferation with IC50 of 20 nM and 30 nM.
Alias
P529
CAS No.
914913-88-5
Molecular Weight
406.43
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
P529
Targets
VEGF-A, bFGF
Molecular Formula
C24H22O6
Chemical Name
3-(4-methoxybenzyloxy)-8-(1-hydroxyethyl)-2-methoxy-6H-benzo[c]chromen-6-one
Solubility
DSMO 81 mg/mL Water
In vitro
Palomid 529 inhibits proliferation and increases apoptosis of endothelial cells. Palomid 529 shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50)
In vivo
Palomid 529 shows a dose-dependent inhibition of the Ad-VEGF-A-driven angiogenesis following Palomid 529 treatment. Palomid 529 decreases AktS473 but not AktT308 signaling. Palomid 529 inhibits tumor growth, angiogenesis, and vascular permeability.
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