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Panobinostat (LBH589)
Cat No.
CEI-0499
Description
(LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC₅₀ values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC₅₀ value is 4.6±1.8 nM.
Alias
LBH589, LBN-589, NVP-LBH590
Appearance
White solid
Product Overview
A HDAC inhibitor
CAS No.
404950-80-7
Molecular Weight
371.27
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
LBH589, LBN-589, NVP-LBH590
Targets
HDAC
Molecular Formula
C₂₁H₂₃N₃O₂
Solubility
DMSO (~100 mM) or EtOH (~ 100 mM)
Shipping Conditions
Gel pack
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