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Plumbagin

Cat No.
CEI-0397
Description
A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
Alias
5-Hydroxy-2-methyl-1, 4-naphthalened­ione
Appearance
Pale yellow solid
Product Overview
A potent histone acetyltransferase (HAT) inhibitor
CAS No.
481-42-5
Molecular Weight
384.27
Purity
>98% by TLC
Storage
-20 centigrade
Synonyms
5-Hydroxy-2-methyl-1,4-naphthalened­ione
Targets
Akt, mTOR
Molecular Formula
C11H8O3
Chemical Name
5-Hydroxy-2-methyl-1,4-naphthalened­ione
Solubility
DMSO (40 mg/ml) or EtOH (25 mg/ml)
Shipping Conditions
Gel pack
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