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Enzymes for Research, Diagnostic and Industrial Use

Regorafenib (methanesulfonate)

Cat No.
CEI-1149
Description
Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
Abbr
Regorafenib(FLT1, KDR, FLT4, PDGFRB, KIT, RET, RAF1)
Alias
FLT, FLT-1, VEGFR-1, VEGFR1
CAS No.
835621-08-4
Molecular Weight
482.82
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Synonyms
FLT, FLT-1, VEGFR-1, VEGFR1
Targets
VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET, Raf-1
IC50
13 nM, 4.2 nM, 46 nM, 22 nM, 7 nM, 1.5 nM, 2.5 nM,
Molecular Formula
C21H15ClF4N4O3
Chemical Name
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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