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TAPI-1

Cat No.
CEI-0680
Description
Inhibitor of TNF-α processing (IC50 = 100 nM), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC50 = 50-100 µM), APP (1-8 µM), IL6R (5- 10 µM), TNFRI (5 -10 µM), TNFRII (25 -50 µM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.
Alias
TNF protease inhibitor-0; C1
Appearance
White solid or clear, colorless film
Product Overview
An inhibitor of TNF-α processing
CAS No.
171235-71-5
Molecular Weight
826.98
Purity
>97% by TLC
Storage
-20 centigrade
Synonyms
TNF protease inhibitor-0; C1
Targets
TNF
Molecular Formula
C 26 H 37 N 5 O 5
Chemical Name
N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
Solubility
DMSO or EtOH
Shipping Conditions
Gel pack
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