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tyrosinase

Cat No.
EXWM-0963
Description
A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state.The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
9002-10-2
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Synonyms
monophenol monooxygenase; phenolase; monophenol oxidase; cresolase; monophenolase; tyrosine-dopa oxidase; monophenol monooxidase; monophenol dihydroxyphenylalanine:oxygen oxidoreductase; N-acetyl-6-hydroxytryptophan oxidase; monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase; o-diphenol:O2 oxidoreductase; phenol oxidase
Reaction
(1) L-tyrosine + O2 = dopaquinone + H2O (overall reaction); (1a) L-tyrosine + ½ O2 = L-dopa; (1b) L-dopa + ½ O2 = dopaquinone + H2O; (2) 2 L-dopa + O2 = 2 dopaquinone + 2 H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-0726
EC No.EC 1.14.18.1
CAS No.9002-10-2
SourceMushroom
Realted Service
Realted Protocols
TYROSINASE Catechol Oxidase Activity -Enzymatic Assay Protocol
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