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Vinorelbine Tartrate

Cat No.
CEI-0562
Description
A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
Appearance
White to off-white solid
Product Overview
An anti-mitotic and antitumor agent
CAS No.
125317-39-7
Molecular Weight
326.35
Purity
>98% by HPLC
Storage
-20 centigrade
Targets
DNMTs
Molecular Formula
C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂
Chemical Name
3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
Solubility
DMSO (100 mM)
Shipping Conditions
Gel Pack
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CAS No.192441-08-0
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