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Amine Oxidase

Official Full Name
Amine Oxidase
Background
Amine oxidase (also known as histaminase) is an enzyme involved in the metabolism, oxidation, and inactivation of histamine within the digestive tract. Bovine plasma amine oxidase has a molecular weight of 170 kDa and an optimum pH of 6.2 for spermine and 7.2 for spermidine. Amine oxidases are divided into two classes:the pyridoxal and copper containing enzyme to which plasma amine oxidase belongs, and the FAD-containing amino oxidases. Natural substrates include catecholamines, tryptamine derivatives and other physiologically active amines. Plasma amine oxidase is used in research requiring nitrogen group transfers. The molecule is composed of two identical polypeptide chains. There are two pyridoxal phosphates and two atoms of Cu+ per molecule. Bovine plasma amine oxidase is inhibited by copper chelating agents, many carboxyl reagents such as cuprizone, hydroxylamine and cyanide. Benzoic acid and benzyl alcohol are both non-competitive inhibitors (KI = 30 and 34mM respectively).
Synonyms
Amine oxidase; EC 1.4.3.21; histaminase; Plasma Amine Oxidase

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-1476
EC No.EC 1.4.3.21
CAS No.
Source
CatalogNATE-0069
EC No.EC 1.4.3.21
CAS No.
SourceBovine Plasma
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