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CTSD

Official Full Name
CTSD
Background
Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D.
Synonyms
CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1874
EC No.EC 3.4.23.5
CAS No.9025-26-7
SourceHuman Spleen
CatalogNATE-1707
EC No.EC 3.4.23.5
CAS No.9025-26-7
SourceE. coli
CatalogEXWM-4287
ProductNamecathepsin D
EC No.EC 3.4.23.5
CAS No.9025-26-7
Source
CatalogNATE-0172
EC No.EC 3.4.23.5
CAS No.9025-26-7
SourceHuman liver
CatalogNATE-0171
EC No.EC 3.4.23.5
CAS No.9025-26-7
SourceBovine spleen
Related Protocols
CATHEPSIN D -Enzymatic Assay Protocol
CATHEPSIN D -Enzymatic Assay Protocol

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