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Poly [ADP-ribose] polymerase 1

Official Full Name
Poly [ADP-ribose] polymerase 1
Background
PARP-1, a nuclear enzyme that synthesizes ADP-ribose polymers from NAD, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. It is involved in base excision repair, both short-patch and long-patch, rejoining DNA strand breaks and plays a role in p53 expression and activation. A high level of basal neuronal DNA damage and PARP activity has been reported in rat brain tissue. PARP-1 was shown to be required for HIV-1 integration into DNA. If PARP-1 is deficient there is no productive HIV-1 infection.
Synonyms
PARP1; poly (ADP-ribose) synthase; ADP-ribosyltransferase (polymerizing); NAD ADP-ribosyltransferase; PARP; PARP-1; NAD+:poly (adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect); NAD+:poly (adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase; EC 2.4.2.30

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-2658
EC No.EC 2.4.2.30
CAS No.58319-92-9
Source
CatalogNATE-0507
EC No.EC 2.4.2.30
CAS No.58319-92-9
SourceE. coli

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