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MDL 28170

Cat No.
CEI-0416
Description
A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.
Alias
Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III
Appearance
White to off-white solid
Product Overview
A potent calpain and cathepsin B inhibitor
CAS No.
88191-84-8
Molecular Weight
628.81
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III
Targets
calpain, cathepsin B
Molecular Formula
C 22 H 26 N 2 O 4
Solubility
DMSO
Shipping Conditions
Gel pack
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