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Phosphodiesterase 5A1 from Human, Recombinant


Cat No.
NATE-0527
Description
PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis.
Abbr
PDE5A, Recombinant (Human)
Alias
PDE5A1; PDE5A
Source
Sf9 cells
Species
Human
Applications
Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors.
Product Overview
N-terminal GST-tagged 126 kDa full-length protein
Form
Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN 20 and 3 mM DTT
Molecular Weight
126 kDa
Unit Definition
One unit will convert 1.0 picomole of 3',5'-cGMP to 5'-GMP per minute at pH 7.4 at 37°C.
Storage
−70°C
Pathway
Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; cGMP effects, organism-specific biosystem
Function
3,5-cyclic-GMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; zinc ion binding
Synonyms
CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A; 3',5'-cyclic-GMP phosphodiesterase, PDE 5A1
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