5'-Nucleotidase from Human, Recombinant

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Cat No.

NATE-0795

Description

5'-nucleotidase is an extracellular enzyme that converts nucleoside-5'−monophosphates to nucleosides with a substrate preference of AMP. Native 5'-nucleotidase is a GPI-anchored protein whose exporession is upregulated by hypoxia. 5'-nucleotidase has many functions in vivo including the generation of extracellular adenosine. 5'-Nucleotidase has various clinical significances. It is a key molecule in the regulation of cancer cells proliferation, migration and invasion in vitro tumor angiogenesis, and tumor immune escape in vivo. Due to this important role, the enzyme is a potential target for cancer research.1 It is also involved in salvage of extracellular nucleotides and plays a key role in the control of tissue homeostasis.

Abbr

AMPase, Recombinant (Human)

Alias

AMPase; UMPase; CD73; NT5E

Source

CHO cells

Species

Human

Package

vial of 6-12 μg

Form

Supplied as a solution containing Tris, NaCl, CaCl2, and 20% glycerol.

Enzyme Commission Number

EC 3.1.3.5

Activity

>15 U/mg

CAS_No

9027-73-0

Molecular Weight

~61 kDa by SDS-PAGE (reducing)

Purity

>90% (SDS-PAGE)

Unit Definition

One unit will hydrolyze 1.0 μmole of inorganic phosphorus from adenosine 5'-monophosphate per min at pH 9.0 at 37 °C.

Storage

Store at -70°C

Synonyms

uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; EC 3.1.3.5; CD73; NT5E; ecto-5'-nucleotidase

"AMPase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1717	5'-Nucleotidase from Microorganism	EC 3.1.3.5	9027-73-0	Microorganism	Inquiry
NATE-1742	Cytosolic 5'-nucleotidase II from Huamn, Recombinant	EC 3.1.3.5	9027-73-0	Human	Inquiry
NATE-0072	Native Crotalus atrox venom 5'-Nucleotidase	EC 3.1.3.5	9027-73-0	Crotalus atrox	Inquiry
EXWM-3654	5'-nucleotidase	EC 3.1.3.5	9027-73-0		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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