Tissue plasminogen activator from Human, Recombinant

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Cat No.

NATE-0920

Description

Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.

Abbr

tPA, Recombinant (Human)

Alias

tPA; PLAT

Source

CHO

Species

Human

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Product Overview

Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59008.71 Dalton. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.

Enzyme Commission Number

EC 3.4.21.68

Activity

580,000 IU/mg

Molecular Weight

59008.71 Da

Purity

Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Stability

Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Buffer

Each mg of t-PA contains 1.7 gr L-arginine, 0.5 gr phosphoric acid and 4 mg tween 80.

Synonyms

Tissue-type plasminogen activator; EC 3.4.21.68; tPA; t-PA; t-plasminogen activator; TPA; T-PA

Publication

Patho-physiological role of BDNF in fibrin clotting

"tPA" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
EXWM-4159	t-plasminogen activator	EC 3.4.21.68	139639-23-9		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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