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IDH


Official Full Name
IDH
Background
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
Synonyms
isocitrate dehydrogenase (NADP+); oxalosuccinate decarboxylase; oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; NADP+-ICDH; NADP+-IDH; IDP; IDP1; IDP2; IDP3

Catalog
Product Name
EC No.
CAS No.
Source
Price
CatalogNATE-1649
EC No.
CAS No.
SourceE. coli
CatalogEXWM-0327
EC No.EC 1.1.1.42
CAS No.9028-48-2
Source
CatalogEXWM-0326
EC No.EC 1.1.1.41
CAS No.9001-58-5
Source
CatalogNATE-1041
EC No.EC 1.1.1.41
CAS No.9001-58-5
SourceE. coli
CatalogNATE-1029
EC No.EC 1.1.1.42
CAS No.9028-48-2
SourceE. coli
CatalogNATE-0351
EC No.EC 1.1.1.42
CAS No.9028-48-2
SourcePichia pastoris
CatalogNATE-0350
EC No.EC 1.1.1.42
CAS No.9028-48-2
SourcePorcine heart
Related Services
Related Protocols
isocitric dehydrogenase -Enzymatic Assay Protocol

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