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Enzyme Activity Measurement for Acetylcholinesterase

Creative Enzymes is a leading company of high-quality bioanalytical services and custom contract research, specialized in enzyme activity analysis serving the needs of clients from all over the world. We work actively and closely with our customers through the process of solving specific problems, mirror target operations, and developing more appropriate methods of enzyme assays. Herein, we are proud to offer the most reliable activity assay for acetylcholinesterase.

Acetylcholinesterase (EC 3.1.1.7; acetylcholine acetylhydrolase; AChE) is a key enzyme in the central and peripheral nervous systems where it is responsible for the hydrolysis of the neurotransmitter acetylcholine (ACh) into choline and acetate. Hydrolysis of ACh by acetylcholinesterase is the key step that terminates the cholinergic signaling pathway, a major intercellular communication pathway that operates through various receptors and activates different intracellular responses in multiple tissues and cell types. This enzyme has been identified in multiple forms with different functions in a variety of tissues of vertebrates and invertebrates. Several acetylcholinesterase forms were encoded by a single gene AChE in the vertebrates by different post-translational modifications and exon splicing. Furthermore, acetylcholinesterase exists as soluble or membrane associated forms in different tissues.

Acetylcholinesterase is the target of many insecticides and warfare terrorism chemical agents such as sarin, VX, and organophosphate insecticides. Therefore, it is meaningful to use acetylcholinesterase in sophisticated versions as biosensors to detect trace pesticides or toxic chemicals in natural samples. Recently, some studies have shown that human cerebral acetylcholinesterase plays a pivotal role in Alzheimer’s disease, and it can be used in screening for new drugs. Additionally, some acetylcholinesterases also can be used to investigate the structure-function relationship of other acetylcholinesterases and their variants. These studies and utilization promote a strong demand for monitoring the activity of acetylcholinesterase.

Creative Enzymes has been providing numerous enzyme assays used in multiple research fields for decades. Equipped with the most advanced instrument, state-of-the-art technology, and a team of extraordinary experts, Creative Enzymes is fully prepared to provide the rapid and precise activity quantitation for acetylcholinesterase. The enzyme activity can be monitored with absorption spectroscopy. The unique advantage of our spectrophotometric analysis allows us to outpace our competitors and assures the reliability of the test results. Overall, Creative Enzymes is your best choice for any research and development activities involving acetylcholinesterase.

The crystal structure of human acetylcholinesterase Figure: The crystal structure of human acetylcholinesterase.
PDB: 4PQE



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