Services

Professional and Cost-saving Solutions

Enzyme Activity Measurement for Beta-Glucuronidase

After years of discovering and developing enzyme assays, Creative Enzymes has emerged as a worldwide leader in the field of activity measurement services. Creative Enzymes has continued growing with the same entrepreneurial and innovative spirit bringing science to commercialization. We firmly believe that the quality of our work and our services is the essential requirement for our high-level customer satisfaction. Creative Enzymes offers the most reliable enzymatic assays for hydrolases such as beta-glucuronidase.

Beta-glucuronidase (EC 3.2.1.31; beta-D-glucuronoside glucuronosohydrolase) is a ubiquitous protein involved in the degradation of glycosaminoglycans and glycoproteins in a wide range of cells of vertebrate and invertebrate tissues. This enzyme specifically hydrolyzes β-linked D-glucuronides to D-glucuronic acid and aglycones.

Functionally, the role of beta-glucuronidase in the migration of mesenchymal cells, the processes of cell-cell recognition, the control of cell growth, cell adhesion, cancer progression and normal cell development, has been well studied in the mammalian system. Moreover, this enzyme is implicated in diverse physiological and pathological processes and therefore is a potential target for the development of drugs, especially in the mediation of drug release.

Furthermore, even a wider range of applications of beta-glucuronidase indicate its promising future, which are seen in the determination of steroid levels in patients, the study of drug metabolism, the structural analysis of glycoproteins, glycosaminoglycans, proteoglycans, models in the differentiation of cells, and also in the oncogenic process. To that end, an understanding of the structures and functions of beta-glucuronidases is of considerable importance, not only to better comprehend their natural roles, but as a pre-requisite to further engineering of such enzymes to modify their specificity and efficiency. In fact, Escherichia coli beta-glucuronidase has already served as a test bed for the development of technologies for directed evolution of protein function.

Thus, reliable activity assays are the key to elucidate the catalytic mechanism of beta-glucuronidase to further gain an insight in the design of new drugs. Creative Enzymes is completely capable of providing the most reliable activity measurement for beta-glucuronidase. The activity of beta-glucuronidase is measured by the spectrophotometric assay which is considered as the most cost-effective method for enzymatic activity quantification. Creative Enzymes surpass its competitors with a quick turnover of the activity assays in response to the request of either a typical activity determination or a customized task. In a word, Creative Enzymes is your best choice and will always look forward to long-term partnership with customers.

Enzyme Activity Measurement for Beta-Glucuronidase Figure: The crystal structure of full-length E. coli beta-glucuronidase.
PDB: 3K46



Inquiry
Related Products
CatalogEXWM-3894
ProductNameβ-glucuronidase
EC No.EC 3.2.1.31
CAS No.9001-45-0
Source
CatalogNATE-1092
EC No.EC 3.2.1.31
CAS No.9001-22-3
SourceE. coli
CatalogNATE-1036
EC No.EC 3.2.1.31
CAS No.9001-45-0
SourceE. coli
CatalogNATE-0769
EC No.EC 3.2.1.31
CAS No.9001-22-3
SourceAlmonds
CatalogNATE-0332
EC No.EC 3.2.1.31
CAS No.9001-45-0
SourceLimpets (Patell...
CatalogNATE-0330
EC No.EC 3.2.1.31
CAS No.9001-45-0
SourceEscherichia col...
CatalogNATE-0329
EC No.EC 3.2.1.31
CAS No.9001-45-0
SourceBovine liver
CatalogNATE-0331
EC No.EC 3.2.1.31
CAS No.9001-45-0
SourceHelix pomatia
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country or Region:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.


Sitemap  Privacy Policy  Terms and Conditions
Copyright ©2011 - 2018 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-516-512-3133
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: